师资队伍

团队介绍：

团队负责人贺祖宏目前已发表SCI论文40多篇，其中1篇文章入选faculty 1000 prime，2篇入选ESI高被引论文。获湖北省青年五四奖章、中华医学科技奖二等奖、湖北省科学技术二等奖、中国妇幼健康科学技术奖二等奖、华夏医学科技一等奖、江苏省青年五四奖章集体。受邀国内外学术会议发言及交流40余次。现担任中国医促会耳内科分会听觉基础研究学组委员，中国生物物理学会听觉、言语和交流分会委员，中国听力医学发展基金会“听觉医学创新与转化”专家委员会副主委，中国中西医结合学会耳聋防治专委会副主委，中国老年医学学会耳科学分会常委，湖北省免疫学会耳鼻喉头颈外科分会常务委员，江苏省发育生物学会听觉科学专委会委员，江苏省生理科学学会青委会副主委，湖北省肝胆疾病学会医工融合分会副主委，全国卫生产业企业管理协会外科技术创新与推广分会理事，湖北省归国青年发展促进会会员，Biophysics Reports青年编委，武汉大学学报编委，《医学新知》编委，Neuroscience编委，Current Chinese Science编委，Flavour and Fragrance Journal编委，Medicine Bulletin编委，Sensory Neuroscience编委，及30多个SCI期刊审稿人。主持国家自然科学基金委优青项目、面上项目、青年项目，江苏省科技重大专项，中国博士后科学基金面上项目，湖北省重点研发计划项目子课题，中央高校基本科研业务费专项资金项目，以骨干参与2项科技部国家重点研发计划项目等，目前个人在研经费总额超3000万元。本团队目前有博士后1人、博士生4人、硕士生2人。


师资队伍：

          负责人贺祖宏（教授、hezuhong@163.com、东南大学生命健康高等研究院）

曹玉玉（2025级博士后）

刘小涛（2023级博士生）

郑莎莎（2024级博士生）

智悦（2024级博士生）

徐行健（2024级硕士生）

蒋露露（2024级硕士生）


研究方向：老年性聋发病机制和干预措施、感音神经性聋致病因素


科研进展：

1.发现了自噬在维持线粒体功能和毛细胞存活过程中发挥重要作用

2.发现了自噬通路上游关键因子FoxG1和TFEB在内耳毛细胞老化进程中的作用机制

3.发现了核因子FoxG1可通过调控自噬影响老化内耳毛细胞炎症易感性

4.构建了靶向内耳细胞的纳米递送体系可有效抑制外界刺激对听觉细胞的损伤


代表性文论：

  1. Zuhong He#, Lingna Guo#, Yilai Shu#, Qiaojun Fang, Han Zhou, Yongze Liu, Dingding Liu, Ling Lu, Xiaoli Zhang, Xiaoqiong Ding, Dong Liu, Mingliang Tang, Weijia Kong, Sushua Sha, Huawei Li*, Xia Gao*, Renjie Chai*. Autophagy protects auditory hair cells against neomycin-induced damage. Autophagy. 2017;13(11):1884-1904.（第一作者）

  2. Zuhong He#, Ming Li#, Qiaojun Fang#, Fuling Liao#, Shengyu Zou, Xia Wu, Haiying Sun, Xueyan Zhao, Yujuan Hu, Xiaoxiang Xu, Sen Chen, Yu Sun, Renjie Chai*, Weijia Kong*. FOXG1 promotes aging inner ear hair cell survival through activation of the autophagy pathway. Autophagy. 2021.（第一作者）（ESI高被引）

  3. Zuhong He#, Shengyu Zou#, Ming Li, Fuling Liao, Xia Wu, Haiying Sun, Xueyan Zhao, Yujuan Hu, Dan Li, Xiaoxiang Xu, Sen Chen, Yu Sun*, Renjie Chai*, Weijia Kong*. The nuclear transcription factor FoxG1 affects the sensitivity of mimetic aging hair cells to inflammation by regulating autophagy pathways. Redox Biology, 2020 Jan;28:101364.（第一作者）（ESI高被引）（F1000推荐）

  4. Jiawen Li#, Zhuowen Hao#, Fangzi Ke, Zhihui Liu, Weilong Wang, Sihui Wen, Fan Wu, Bowen Xu, Miao He,Shengyu Zou, Xiong Chen*, Jingfeng Li*, Zuhong He*. A Multifunctional Nanodelivery System Modified by Fusion Peptides acts as Teriparatide Carrier for Noise-Induced Hearing Loss Therapy. Advanced Science，2025 Feb 7:e2408798. （最后通讯）

  5. Yongjie Wei, Yuhua Zhang, Wei Cao, Nan Cheng, Yun Xiao, Yongjun Zhu, Yan Xu, Lei Zhang, Lingna Guo, Jun Song, Su-hua Sha, Buwei Shao, Fang Ma, Jingwen Yang, Zheng Ying*, Zuhong He*, Renjie Chai*, Qiaojun Fang*, Jianming Yang*. RONIN/HCF1-TFEB Axis Protects against D-galactose-Induced Cochlear Hair Cell Senescence through Autophagy Activation.Advanced Science，2025（并列通讯作者）

  6. Yanyan Ding, Wei Meng, Weijia Kong, Zuhong He*, Renjie Chai*. The role of FoxG1 in the inner ear. Frontiers in Cell and Developmental Biology. 03 December 2020.（并列通讯作者）

  7. Peng-Wei Ma，Wei-Long Wang，Jia-Wei Chen，Hao Yuan，Pei-Heng Lu，Wei Gao，Xue-Rui Ding，Yu-Qiang Lun，Rui Liang，Zu-Hong He*，Qian Yang*，Lian-Jun Lu*. Treatment with the Ferroptosis Inhibitor Ferrostatin-1 Attenuates Noise-Induced Hearing Loss by Suppressing Ferroptosis and Apoptosis.Oxidative Medicine and Cellular Longevity.2022.（并列通讯作者）

  8. Yu-rong Mu#, Sheng-yu Zou#, Ming Li, Yan-yan Ding, Xiang Huang, Zu-hong He*, Wei-jia Kong*.Role and mechanism of FOXG1-related epigenetic modifications in cisplatin-induced hair cell damage.Frontiers in Molecular Neuroscience.26 April 2023.（并列通讯作者）

  9. Ying Sun, Shengyu Zou, Xiaoxiang Xu, Shan Xu, Haiying Sun, Mingliang Tang, Weijia Kong, Xiong Chen*, Zuhong He*.Inhibition of the cGAS STING Pathway Reduces Cisplatin-induced Inner Ear Hair Cell Damage.Neuroscience Bulletin. 2024. 10.1007/s12264-024-01334-8. （并列通讯作者）（封面）

  10. Zuhong He#, Qiaojun Fang#, He Li#, Buwei Shao, Yuan Zhang, Yuhua Zhang, Xiao Han, Rongrong Guo, Cheng Cheng, Lingna Guo, Lusen Shi, Ao Li, Chenjie Yu, Weijia Kong Chunjie Zhao*, Xia Gao*, Renjie Chai*. The role of FoxG1 in the development and survival of mouse cochlear hair cells.Neuropharmacology. 2019 Jan;144:43-57.（第一作者）

  11. Zuhong He#, Shasha Zhang#, Qin Song#, Wenyan Li, Dong Liu, Huawei Li, Mingliang Tang*, Renjie Chai*. The structural development of primary cultured hippocampal neurons on a graphene substrate. Colloids Surf B Biointerfaces. 2016 Oct 1;146:442-51. （第一作者）

  12. Yanqiu Zhang#, Wei Li#, Zuhong He#, Yunfeng Wang#, Buwei Shao, Cheng Cheng, Shasha Zhang, Mingliang Tang, Xiaoyun Qian, Weijia Kong, Hui Wang*, Renjie Chai*, Xia Gao*. Pre-treatment With Fasudil Prevents Neomycin-Induced Hair Cell Damage by Reducing the Accumulation of Reactive Oxygen Species. Frontiers in Molecular Neuroscience. 2019 Nov 6;12:264. (并列第一作者)

  13. Zuhong He, Ming Li, Shengyu Zou, Fuling Liao, Yanyan Ding, Hongguo Su, Xinfeng Wei, Chunjiang Wei, Yurong Mu, Weijia Kong. Protection and Prevention of Age-Related Hearing Loss. Advances in Experimental Medicine and Biology. 2019;1130:59-71. （第一作者）

  14. Zuhong He#, Shan Sun#, Muhammad Waqas, Xiaoli Zhang, Fuping Qian, Cheng Cheng, Mingshu Zhang, Shasha Zhang, Yongming Wang, Mingliang Tang, Huawei Li*, Renjie Chai*. Reduced TRMU expression increases the sensitivity of hair-cell-like HEI-OC-1 cells to neomycin damage in vitro. Scientific reports. 2016 Jul 13;6:29621.（第一作者）

  15. Zuhong He#, Qiaojun Fang#, Muhammad Waqas#, Xia Wu, Cheng Cheng, Li He, Yu Sun, Weijia Kong*, Renjie Chai*. Role of autophagy in auditory system development and survival. Journal of Otorhinolaryngology, Hearing and Balance Medicine. 2018, 1, 7.（第一作者）

  16. Zuhong He#*, Yanyan Ding#, Yurong Mu, Xiaoxiang Xu, Weijia Kong, Renjie Chai*, Xiong Chen*. Stem Cell-Based Therapies in Hearing Loss. Frontiers in Cell and Developmental Biology. 2021 Oct 21;9:730042. （第一作者及并列通讯作者）(IF6.684)

  17. Xia Wu, Shengyu Zou, Fan Wu, Zuhong He*, Weijia Kong*. Role of microRNA in Inner Ear Stem Cells and Related Research Progress. American Journal of Stem Cells. 2020 Apr 25;9(2):16-24.（并列通讯作者）(IF1.8)

  18. Chunjiang Wei, Weijia Kong, Zuhong He*. Application of gene therapy in auditory system diseases. Stemedicine. VOL 1 NO 1 (2020). （通讯作者）

  19. Zuhong He#, Song Pan#, Hong-Wei Zheng#, Qiao-Jun Fang, Kayla Hill, Su-Hua Sha. Treatment with calcineurin inhibitor FK506 attenuates noise-induced hearing loss. Frontiers in Cell and Developmental Biology. 2021 Mar 12;9:648461.（第一作者）

  20. Zuhong He#*, Weijia Kong, Shengyu Zou, Hai Huang, Suhua Sha. Editorial: Hearing Loss: From Pathogenesis to Treatment.Frontiers in Cellular Neuroscience. 2022 Jun 10;16:907483. （第一作者及通讯作者）

  21. Xiaoxiang Xu, Kun Lin, Fengrui Jia, Shuang Li, Zuhong He*, Xiong Chen. Defect-Rich and Single-Crystalline PdCu Ultrathin Nanowires Promoting Ethanol Oxidation Electrocatalysis. ACS Appl. Energy Mater.2022. https://doi.org/10.1021/acsaem.2c01952. （并列通讯作者）

  22. Ying Sun，Shengyu Zou，Zuhong He*，Xiong Chen*. The Role of Autophagy and Ferroptosis in Sensorineural Hearing Loss.Frontiers in Neuroscience. 10.3389/fnins.2022.1068611（并列通讯作者）

  23. JieyuQi#,XiaolongFu#,LiyanZhang#,FangzhiTan#,NianciLi,QiuhanSun,XiaojieHu,ZuhongHe*,MingXia*,RenjieChai*. Current AAV-mediated gene therapy in sensorineural hearing loss.Fundamental Research. doi:10.1016/j.fmre.2022.08.015.（并列通讯作者）

  24. Shengyu Zou, Qingyin Zheng, Yu Sun, Xiaolong Fu, Wenjie Zhou, Zuhong He*. Editorial: Hearing Loss: From Pathogenesis to Treatment Volume II. Frontiers in Cellular Neuroscience. DOI: 10.3389/fncel.2023.1309592.（第一作者及通讯作者）

  25. Jipeng Wang#, Gang Deng#, Shuyi Wang, Shuang Li, Peng Song, Kun Lin, Xiaoxiang Xu*, Zuhong He*. Enhancing regenerative medicine: the crucial role of stem cell therapy.Front Neurosci. 2024 Feb 8:18:1269577.（通讯作者）

  26. Peng Zhou, Ling Li, Xiaoping Ming, Wanyue Cai, Bin Hao, Yifan Hu, Zuhong He*, Xiong Chen*. Causal relationship between psychiatric disorders and sensorineural hearing loss: A bidirectional two-sample mendelian randomization analysis. J Psychosom Res. 2024 Mar 7:179:111641. （并列通讯作者）

  27. Zou S, Zheng Q, Sun Y, Fu X, Zhou W, He Z*. Editorial: Gene therapy for hearing loss: from mechanism to clinic, volume II. Front Neurosci. 2024 May 14:18:1412981.通讯作者）

  28. Haiying Sun#, Yujuan Hu#, Yun Zhu#, Juanjuan Hu, Jie Yuan, Zuhong He*, Huamao Cheng*. Case report: Microsurgical resection of a giant triple dumbbell shaped jugular foramen Schwannoma via retrosigmoid and transcervical approach. Front Oncol. 2024 Oct 23:14:1432835. （并列通讯作者）

  29. Zehua Lin#，Weisong Cai#，Yuechen Sun#，Baoai Han，Yifan Hu，Zuhong He*，Xiong Chen*. Mechanism and application of mesenchymal stem cells and their secreting extracellular vesicles in regulating CD4+T cells in immune diseases. Biophysics Reports. 2024 Dec 31;10(6):403-415.（并列通讯作者）

  30. 贺祖宏，李明，邹圣宇，丁言言，苏红果，韦春江，韦新凤，慕雨容，孔维佳.老年性聋的发病机制及干预研究进展,中华耳鼻咽喉头颈外科杂志,2020,55(11):1105-1110.（第一作者）

  31. 李采霓，徐晓翔，陈雄，贺祖宏。线粒体自噬在感音神经性耳聋中的研究进展，实用医院临床杂志，2023,20（4）8-11.（通讯作者）

  32. Jieyu Qi, Fangzhi Tan, Liyan Zhang, Ling Lu, Hongyang Wang, Wenyan Li, Wenwen Liu, Xiaolong Fu, Zuhong He, Xiaoqiong Ding, Shan Sun, Qiaojun Fang, Yaodong Dong, Xuewei Zhu, Busheng Tong, Xianbao Cao, Min Guo, Xinmiao Fan, Qin Wang, Lu Ma, Tianhong Zhang, Yafeng Yu, Yongxin Li, Jiangang Fan, Yong Cui, Peina Wu, Hongzheng Zhang, Jie Tang, Weiwei Guo, Dingjun Zha, Fanglei Ye, Shuangba He, Wei Cao, Jianming Yang, Xiaoyun Qian, Yu Zhao, Jingwu Sun, Xiaowei Chen, Yu Sun, Ming Xia, Qiuju Wang, Huijun Yuan, Yong Feng, Weijia Kong, Shiming Yang, Haibo Wang, Maoli Duan, Xia Gao, Huawei Li, Lei Xu, Renjie Chai. Clinical practice guidelines for gene therapy to treat hereditary hearing loss. Interdisciplinary Medicine. 16 March 2024 （第一个耳聋基因治疗英文临床指南）

  33. Fan Wu, Guisheng Chen, Rui Hu, Peiwen Liu, Jintao Lou, Wenji Zhao, Zuhong He, Suhua Sha, Yiqing Zheng. AAVR Expression is Essential for AAV Vector Transduction in Sensory Hair Cells. Advanced Science，2025 Jan 7:e2408873.

  34. Fan Wu, Kayla Hill, Qiaojun Fang, Zuhong He, Hongwei Zheng, Xianren Wang, Hao Xiong, Suhua Sha. Traumatic-noise-induced hair cell death and hearing loss is mediated by activation of CaMKKβ. Cellular And Molecular Life Sciences. 2022 Apr 19;79(5):249. (IF9.207)